Alphabirth adds new challenges The Binding of Isaac: Rebirth that each unlock specific items, trinkets, or pickups for Isaac on later runs.
Name | Pack | Description | Items | Unlocks |
---|---|---|---|---|
Empty | Only active items spawn, use Void and Abyss to complete the challenge. | Abyss + Void | Fehu (Rune) | |
Exploding Head Syndrome! | Isaac is blindfolded and only shoots transcendent ipecac tears in the direction he moves. | Pseudobulbar Affect + Ipecac + Continuum | Glitched Pickups | |
Faust | Isaac starts with 12 heart containers; every floor he is automatically teleported to the boss room. He must use his 100% "Deal with the Devil" wisely as he has no access to treasure rooms or shops. | Emperor's Crown + Goat Head | Emperor's Crown | |
For The Hoard! | Use your bums and damage upgrades from Hoarder to hoard every pickup throughout the run. | Hoarder + Bum Friend + Key Bum | Naudiz (Rune) | |
It Follows | Avoid the Hush laser that slowly follows Isaac. | ~ | Apparition | |
Restless Leg Syndrome! | Bombs spawn at Isaac's feet if he stands still for longer than 2 seconds. The damage boost from Hot Coals further encourages continual movement. | Hot Coals | Sowilo (Rune) | |
S#!7iest Day Ever! | Isaac is blindfolded and must use Brown Eye poops as his main source of damage. | Brown Eye + Brother Bobby + Nun's Habit + 9 Volt | Brown Eye | |
The Collector | Isaac must choose between using pickups traditionally, hoarding them as a way to get extra damage from Hoarder, or absorbing them with Cauldron to gain extra items. | Cauldron + Hoarder | Gebo (Rune) |